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Differentiated Nomological Networks of Internalizing, Externalizing, and the General Factor of Psychopathology (“P factor”) in Emerging Adolescence in the ABCD study

Sarah J. Brislin, Meghan E. Martz, Sonalee Joshi, Elizabeth R. Duval, Arianna Gard, D. Angus Clark, Luke Hyde, Brian Hicks, Aman Taxali, Mike Angstadt, Saige Rutherford, Mary M. Heitzeg, Chandra Sripada

Abstract

Introduction

Structural models of psychopathology consistently identify internalizing (INT) and externalizing (EXT) specific factors as well as a superordinate factor that captures their shared variance, the P factor. Questions remain, however, about meaning of thesedata-driven dimensions and the interpretability and distinguishability of the larger nomological networks in which they are embedded.

Methods

The sample consisted of 10,645youth aged 9 to 10 years participating in the multisite Adolescent Brain and Cognitive Development (ABCD) Study. P, INT, and EXT were modeled usingthe parent-rated Child Behavior Checklist (CBCL).Patterns of associations were examined with variables drawn from diverse domains including: demographics, psychopathology, temperament, family history of substance use and psychopathology, school and family environment, and cognitive ability, using instruments based on youth-, parent-, and teacher-report and behavioral task performance.

Results

P exhibited a broad pattern of statisticallysignificant associations with risk variables across all domains assessed, including temperament, neurocognition, and social adversity. The specific factors exhibited more domain-specific patterns of associations, with INT exhibiting greater fear/distress and EXT exhibiting greater impulsivity.

Conclusions

In this largest study of hierarchical models of psychopathology to date, we found that P, INT, and EXT exhibit well differentiated nomological networks that are interpretable in terms of neurocognition, impulsivity, fear/distress, and social adversity. These networks were, in contrast, obscured when relying on the a priori internalizing and externalizing dimensions of the CBCL scales. Our findings add to the evidence for the validity of P, INT, and EXT as theoretically and empirically meaningful broad psychopathology liabilities.

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