VLE/KBE-4/cadd_integration #65
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Strexas
reviewed
Sep 25, 2024
Strexas
approved these changes
Sep 30, 2024
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Implemented cadd tool
fetch_cadd_scores:Returns CADD scores for a given chromosome and genomic position or range (SNV or region).
Handles single-nucleotide variants (SNVs) by constructing call to cadd tool URLs.
evaluate_cadd_score:Fetches the highest PHRED score for each genomic position using the fetch_cadd_scores function.
Returns the highest PHRED score for evaluation, or an error message if unavailable.
add_cadd_eval_column:Adds a new column (cadd_eval(PHRED)) and applies the
evaluate_cadd_scorefunction row by row in the DataFrame to compute and store CADD score evaluations.