An SGC Open Chemistry Networks Project 13 devoted to Pfal RBBP4 orthologue. The aim of the project is to find a small molecule that binds a Plasmodium WD40 repeat protein, using a human orthologue as the starting point.
You contribute synthetic chemistry and in return the SGC offers biology. Together we can generate tool compounds to understand biology and validate drug targets to help cure disease. Everything is open, with all content governed by a CC-BY-4.0 licence.
If this sounds interesting, and you agree to the simple RULES, you can get started.
For the science background, head to the wiki or check out the living paper that is being written here.
For answers to all the questions you have, go to the FAQs.
If you'd like to contact someone to talk about contributing, then write something in an Issue (see the tab above), which is a good way to communicate openly. Issues describe what currently needs doing and act as a discussion forum - you need a Github account but it's super easy and not spammy. There's also an email address (chemistry@thesgc.org) you can use to ask questions. You can read more about all this in the "How To" Area.
People involved in this CNP:
Prof. Matthew Todd, UCL, Head of Chemistry Networks at the SGC @mattodd
Dr. Levon Halabelian, UoT, SGC Toronto
Peter Loppnau, Protein Production, UoT, SGC Toronto
Mohsen Alamoudi, UCL, PhD candidate in School of Pharmacy, UCL @MohsenAlamoudi
Fengling Li, Biopysical assays, UoT, SGC Toronto
You can see other contributors in the Issues (tab above).
The licence for the content of this project is, unless otherwise stated, and as for all OCN projects, CC-BY-4.0. This means you can do whatever you like with the project content, including making money, provided you cite the project.
This project is part of the SGC's Open Chemistry Networks initiative.
and is also connected with Open Source Malaria
