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2 changes: 1 addition & 1 deletion 02-Chapter2.Rmd
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Expand Up @@ -151,7 +151,7 @@ Data are stored in data structures. There are many different data structures in
+ **Data frames:** similar to a matrix but can contain different data types and additional attributes such as row names (and is one of the most common data structures in environmental health research). Tibbles are a stricter type of data frame implemented in the *tidyverse* package.
+ **Lists:** a special type of vector that acts as a container – other data structures can be stored within the list, and lists can contain other lists. Lists can contain elements that are different data structures.

```{r, echo=FALSE, fig.align = "center", fig.cap= "Created with *BioRender.com*"}
```{r, echo=FALSE, fig.align = "center"}
knitr::include_graphics("Module2_1_Input/Image5.png")
```

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2 changes: 1 addition & 1 deletion 03-Chapter3.Rmd
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# (PART\*) Chapter 3 Basics of <br>Data Analysis and Visualizations {-}
# (PART\*) Chapter 3 Basics of Data <br>Analysis and Visualizations {-}

# 3.1 Data Visualizations

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2 changes: 1 addition & 1 deletion 04-Chapter4.Rmd
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# (PART\*) Chapter 4 Converting Wet Lab Data into Dry Lab Analyses {-}
# (PART\*) Chapter 4 Converting Wet <br>Lab Data into Dry Lab <br>Analyses {-}

# 4.1 Overview of Experimental Design and Example Data

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2 changes: 1 addition & 1 deletion 05-Chapter5.Rmd
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# (PART\*) Chapter 5 Machine Learning & Artificial Intelligence {-}
# (PART\*) Chapter 5 Machine Learning <br>& Artificial Intelligence {-}

# 5.1 Introduction to Artificial Intelligence, Machine Learning, and Predictive Modeling for Environmental Health

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6 changes: 3 additions & 3 deletions 06-Chapter6.Rmd
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# (PART\*) Chapter 6 Applications in Toxicology & Exposure Science {-}
# (PART\*) Chapter 6 Applications in <br>Toxicology & Exposure <br>Science {-}

# 6.1 Descriptive Cohort Analyses

Expand Down Expand Up @@ -525,7 +525,7 @@ Using a more expanded demographics file ("Module6_1_TYKInput.xlsx"), create a de
+ The two new variables (home location and home type) included
+ The table split by which site the participant visited
+ Variable names and values presented in a publication-quality format (first letters capitalized, spaces between words, no underscores)
:::
:::

# 6.2 -Omics and System Biology: Transcriptomic Applications

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</label>

:::tyk

Using "Module6_2_TYKInput1.csv" (gene counts) and "Module6_2_TYKInput2.csv" (sample info) data sets, which have already been run through the QC process described in this module and are ready for analysis:

1. Conduct a differential expression analysis associated with "Season" using DESeq2. (Don't worry about including any covariates or using RUV).
2. Find the number of significant differentially expressed genes associated with "Season", at the .05 level.
:::

# 6.3 Mixtures Analysis Methods Part 1: Overview and Example with Quantile G-Computation

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2 changes: 1 addition & 1 deletion 07-Chapter7.Rmd
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# (PART\*) Chapter 7 Environmental Health Database Mining {-}
# (PART\*) Chapter 7 Environmental<br> Health Database Mining {-}

# 7.1 Comparative Toxicogenomics Database

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36 changes: 36 additions & 0 deletions VennDiagram.2024-12-06_13-22-00.944893.log
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INFO [2024-12-06 13:22:00] $x
INFO [2024-12-06 13:22:00] list(exp_filt$`Gene Symbol`, met_filt$`Gene Symbol`)
INFO [2024-12-06 13:22:00]
INFO [2024-12-06 13:22:00] $category.names
INFO [2024-12-06 13:22:00] c("Altered Expression", "Altered Methylation")
INFO [2024-12-06 13:22:00]
INFO [2024-12-06 13:22:00] $filename
INFO [2024-12-06 13:22:00] NULL
INFO [2024-12-06 13:22:00]
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INFO [2024-12-06 13:22:00]
INFO [2024-12-06 13:22:00]
36 changes: 36 additions & 0 deletions VennDiagram.2024-12-06_14-17-20.877928.log
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INFO [2024-12-06 14:17:20] $x
INFO [2024-12-06 14:17:20] list(exp_filt$`Gene Symbol`, met_filt$`Gene Symbol`)
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $category.names
INFO [2024-12-06 14:17:20] c("Altered Expression", "Altered Methylation")
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $filename
INFO [2024-12-06 14:17:20] NULL
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $output
INFO [2024-12-06 14:17:20] F
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $cat.cex
INFO [2024-12-06 14:17:20] [1] 1.15
INFO [2024-12-06 14:17:20]
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INFO [2024-12-06 14:17:20] [1] "bold"
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $cat.default.pos
INFO [2024-12-06 14:17:20] [1] "outer"
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $cat.pos
INFO [2024-12-06 14:17:20] c(-27, 27)
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INFO [2024-12-06 14:17:20] c(0.055, 0.055)
INFO [2024-12-06 14:17:20]
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INFO [2024-12-06 14:17:20] c("#440154ff", "#21908dff")
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] $fill
INFO [2024-12-06 14:17:20] c(alpha("#440154ff", 0.3), alpha("#21908dff", 0.3))
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20] [[12]]
INFO [2024-12-06 14:17:20]
INFO [2024-12-06 14:17:20]
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64 changes: 32 additions & 32 deletions advanced-multi-group-comparisons.html

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12 changes: 6 additions & 6 deletions chemical-read-across-for-toxicity-predictions.html
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<meta name="author" content="Rager Lab" />


<meta name="date" content="2024-10-17" />
<meta name="date" content="2024-12-06" />

<meta name="viewport" content="width=device-width, initial-scale=1" />
<meta name="apple-mobile-web-app-capable" content="yes" />
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<li class="chapter" data-level="" data-path="improving-coding-efficiencies.html"><a href="improving-coding-efficiencies.html#concluding-remarks-7"><i class="fa fa-check"></i>Concluding Remarks</a></li>
<li class="chapter" data-level="" data-path="improving-coding-efficiencies.html"><a href="improving-coding-efficiencies.html#additional-resources-2"><i class="fa fa-check"></i>Additional Resources</a></li>
</ul></li>
<li class="part"><span><b>Chapter 3 Basics of <br>Data Analysis and Visualizations</b></span></li>
<li class="part"><span><b>Chapter 3 Basics of Data <br>Analysis and Visualizations</b></span></li>
<li class="chapter" data-level="" data-path="data-visualizations.html"><a href="data-visualizations.html"><i class="fa fa-check"></i>3.1 Data Visualizations</a>
<ul>
<li class="chapter" data-level="" data-path="data-visualizations.html"><a href="data-visualizations.html#introduction-to-data-visualizations"><i class="fa fa-check"></i>Introduction to Data Visualizations</a></li>
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<li class="chapter" data-level="" data-path="intoduction-to-statistical-tests.html"><a href="intoduction-to-statistical-tests.html#statistical-evaluations-of-categorical-data-using-the-chi-squared-test-and-fishers-exact-test"><i class="fa fa-check"></i>Statistical Evaluations of Categorical Data using the Chi-Squared Test and Fisher’s Exact Test</a></li>
<li class="chapter" data-level="" data-path="intoduction-to-statistical-tests.html"><a href="intoduction-to-statistical-tests.html#concluding-remarks-11"><i class="fa fa-check"></i>Concluding Remarks</a></li>
</ul></li>
<li class="part"><span><b>Chapter 4 Converting Wet Lab Data into Dry Lab Analyses</b></span></li>
<li class="part"><span><b>Chapter 4 Converting Wet <br>Lab Data into Dry Lab <br>Analyses</b></span></li>
<li class="chapter" data-level="" data-path="overview-of-experimental-design-and-example-data.html"><a href="overview-of-experimental-design-and-example-data.html"><i class="fa fa-check"></i>4.1 Overview of Experimental Design and Example Data</a>
<ul>
<li class="chapter" data-level="" data-path="overview-of-experimental-design-and-example-data.html"><a href="overview-of-experimental-design-and-example-data.html#introduction-to-training-module-12"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
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<li class="chapter" data-level="" data-path="advanced-multi-group-comparisons.html"><a href="advanced-multi-group-comparisons.html#ancova-example"><i class="fa fa-check"></i>ANCOVA Example</a></li>
<li class="chapter" data-level="" data-path="advanced-multi-group-comparisons.html"><a href="advanced-multi-group-comparisons.html#concluding-remarks-17"><i class="fa fa-check"></i>Concluding Remarks</a></li>
</ul></li>
<li class="part"><span><b>Chapter 5 Machine Learning &amp; Artificial Intelligence</b></span></li>
<li class="part"><span><b>Chapter 5 Machine Learning <br>&amp; Artificial Intelligence</b></span></li>
<li class="chapter" data-level="" data-path="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html"><a href="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html"><i class="fa fa-check"></i>5.1 Introduction to Artificial Intelligence, Machine Learning, and Predictive Modeling for Environmental Health</a>
<ul>
<li class="chapter" data-level="" data-path="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html"><a href="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html#introduction-to-training-module-18"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
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<li class="chapter" data-level="" data-path="unsupervised-machine-learning-part-2-additional-clustering-applications.html"><a href="unsupervised-machine-learning-part-2-additional-clustering-applications.html#variable-contributions"><i class="fa fa-check"></i>Variable Contributions</a></li>
<li class="chapter" data-level="" data-path="unsupervised-machine-learning-part-2-additional-clustering-applications.html"><a href="unsupervised-machine-learning-part-2-additional-clustering-applications.html#concluding-remarks-22"><i class="fa fa-check"></i>Concluding Remarks</a></li>
</ul></li>
<li class="part"><span><b>Chapter 6 Applications in Toxicology &amp; Exposure Science</b></span></li>
<li class="part"><span><b>Chapter 6 Applications in <br>Toxicology &amp; Exposure <br>Science</b></span></li>
<li class="chapter" data-level="" data-path="descriptive-cohort-analyses.html"><a href="descriptive-cohort-analyses.html"><i class="fa fa-check"></i>6.1 Descriptive Cohort Analyses</a>
<ul>
<li class="chapter" data-level="" data-path="descriptive-cohort-analyses.html"><a href="descriptive-cohort-analyses.html#introduction-to-training-module-23"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
Expand Down Expand Up @@ -463,7 +463,7 @@
<li class="chapter" data-level="" data-path="toxicokinetic-modeling.html"><a href="toxicokinetic-modeling.html#reverse-tk-calculating-administered-equivalent-doses-for-toxcast-bioactive-concentrations"><i class="fa fa-check"></i>Reverse TK: Calculating Administered Equivalent Doses for ToxCast Bioactive Concentrations</a></li>
<li class="chapter" data-level="" data-path="toxicokinetic-modeling.html"><a href="toxicokinetic-modeling.html#comparing-equivalent-doses-estimated-to-elicit-toxicity-hazard-to-external-exposure-estimates-exposure-for-chemical-prioritization-by-bioactivity-exposure-ratios-bers"><i class="fa fa-check"></i>Comparing Equivalent Doses Estimated to Elicit Toxicity (Hazard) to External Exposure Estimates (Exposure), for Chemical Prioritization by Bioactivity-Exposure Ratios (BERs)</a></li>
</ul></li>
<li class="part"><span><b>Chapter 7 Environmental Health Database Mining</b></span></li>
<li class="part"><span><b>Chapter 7 Environmental<br> Health Database Mining</b></span></li>
<li class="chapter" data-level="" data-path="comparative-toxicogenomics-database.html"><a href="comparative-toxicogenomics-database.html"><i class="fa fa-check"></i>7.1 Comparative Toxicogenomics Database</a>
<ul>
<li class="chapter" data-level="" data-path="comparative-toxicogenomics-database.html"><a href="comparative-toxicogenomics-database.html#introduction-to-training-module-30"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
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12 changes: 6 additions & 6 deletions coding-best-practices.html
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<meta name="author" content="Rager Lab" />


<meta name="date" content="2024-10-17" />
<meta name="date" content="2024-12-06" />

<meta name="viewport" content="width=device-width, initial-scale=1" />
<meta name="apple-mobile-web-app-capable" content="yes" />
Expand Down Expand Up @@ -254,7 +254,7 @@
<li class="chapter" data-level="" data-path="improving-coding-efficiencies.html"><a href="improving-coding-efficiencies.html#concluding-remarks-7"><i class="fa fa-check"></i>Concluding Remarks</a></li>
<li class="chapter" data-level="" data-path="improving-coding-efficiencies.html"><a href="improving-coding-efficiencies.html#additional-resources-2"><i class="fa fa-check"></i>Additional Resources</a></li>
</ul></li>
<li class="part"><span><b>Chapter 3 Basics of <br>Data Analysis and Visualizations</b></span></li>
<li class="part"><span><b>Chapter 3 Basics of Data <br>Analysis and Visualizations</b></span></li>
<li class="chapter" data-level="" data-path="data-visualizations.html"><a href="data-visualizations.html"><i class="fa fa-check"></i>3.1 Data Visualizations</a>
<ul>
<li class="chapter" data-level="" data-path="data-visualizations.html"><a href="data-visualizations.html#introduction-to-data-visualizations"><i class="fa fa-check"></i>Introduction to Data Visualizations</a></li>
Expand Down Expand Up @@ -294,7 +294,7 @@
<li class="chapter" data-level="" data-path="intoduction-to-statistical-tests.html"><a href="intoduction-to-statistical-tests.html#statistical-evaluations-of-categorical-data-using-the-chi-squared-test-and-fishers-exact-test"><i class="fa fa-check"></i>Statistical Evaluations of Categorical Data using the Chi-Squared Test and Fisher’s Exact Test</a></li>
<li class="chapter" data-level="" data-path="intoduction-to-statistical-tests.html"><a href="intoduction-to-statistical-tests.html#concluding-remarks-11"><i class="fa fa-check"></i>Concluding Remarks</a></li>
</ul></li>
<li class="part"><span><b>Chapter 4 Converting Wet Lab Data into Dry Lab Analyses</b></span></li>
<li class="part"><span><b>Chapter 4 Converting Wet <br>Lab Data into Dry Lab <br>Analyses</b></span></li>
<li class="chapter" data-level="" data-path="overview-of-experimental-design-and-example-data.html"><a href="overview-of-experimental-design-and-example-data.html"><i class="fa fa-check"></i>4.1 Overview of Experimental Design and Example Data</a>
<ul>
<li class="chapter" data-level="" data-path="overview-of-experimental-design-and-example-data.html"><a href="overview-of-experimental-design-and-example-data.html#introduction-to-training-module-12"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
Expand Down Expand Up @@ -345,7 +345,7 @@
<li class="chapter" data-level="" data-path="advanced-multi-group-comparisons.html"><a href="advanced-multi-group-comparisons.html#ancova-example"><i class="fa fa-check"></i>ANCOVA Example</a></li>
<li class="chapter" data-level="" data-path="advanced-multi-group-comparisons.html"><a href="advanced-multi-group-comparisons.html#concluding-remarks-17"><i class="fa fa-check"></i>Concluding Remarks</a></li>
</ul></li>
<li class="part"><span><b>Chapter 5 Machine Learning &amp; Artificial Intelligence</b></span></li>
<li class="part"><span><b>Chapter 5 Machine Learning <br>&amp; Artificial Intelligence</b></span></li>
<li class="chapter" data-level="" data-path="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html"><a href="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html"><i class="fa fa-check"></i>5.1 Introduction to Artificial Intelligence, Machine Learning, and Predictive Modeling for Environmental Health</a>
<ul>
<li class="chapter" data-level="" data-path="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html"><a href="introduction-to-artificial-intelligence-machine-learning-and-predictive-modeling-for-environmental-health.html#introduction-to-training-module-18"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
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<li class="chapter" data-level="" data-path="unsupervised-machine-learning-part-2-additional-clustering-applications.html"><a href="unsupervised-machine-learning-part-2-additional-clustering-applications.html#variable-contributions"><i class="fa fa-check"></i>Variable Contributions</a></li>
<li class="chapter" data-level="" data-path="unsupervised-machine-learning-part-2-additional-clustering-applications.html"><a href="unsupervised-machine-learning-part-2-additional-clustering-applications.html#concluding-remarks-22"><i class="fa fa-check"></i>Concluding Remarks</a></li>
</ul></li>
<li class="part"><span><b>Chapter 6 Applications in Toxicology &amp; Exposure Science</b></span></li>
<li class="part"><span><b>Chapter 6 Applications in <br>Toxicology &amp; Exposure <br>Science</b></span></li>
<li class="chapter" data-level="" data-path="descriptive-cohort-analyses.html"><a href="descriptive-cohort-analyses.html"><i class="fa fa-check"></i>6.1 Descriptive Cohort Analyses</a>
<ul>
<li class="chapter" data-level="" data-path="descriptive-cohort-analyses.html"><a href="descriptive-cohort-analyses.html#introduction-to-training-module-23"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
Expand Down Expand Up @@ -463,7 +463,7 @@
<li class="chapter" data-level="" data-path="toxicokinetic-modeling.html"><a href="toxicokinetic-modeling.html#reverse-tk-calculating-administered-equivalent-doses-for-toxcast-bioactive-concentrations"><i class="fa fa-check"></i>Reverse TK: Calculating Administered Equivalent Doses for ToxCast Bioactive Concentrations</a></li>
<li class="chapter" data-level="" data-path="toxicokinetic-modeling.html"><a href="toxicokinetic-modeling.html#comparing-equivalent-doses-estimated-to-elicit-toxicity-hazard-to-external-exposure-estimates-exposure-for-chemical-prioritization-by-bioactivity-exposure-ratios-bers"><i class="fa fa-check"></i>Comparing Equivalent Doses Estimated to Elicit Toxicity (Hazard) to External Exposure Estimates (Exposure), for Chemical Prioritization by Bioactivity-Exposure Ratios (BERs)</a></li>
</ul></li>
<li class="part"><span><b>Chapter 7 Environmental Health Database Mining</b></span></li>
<li class="part"><span><b>Chapter 7 Environmental<br> Health Database Mining</b></span></li>
<li class="chapter" data-level="" data-path="comparative-toxicogenomics-database.html"><a href="comparative-toxicogenomics-database.html"><i class="fa fa-check"></i>7.1 Comparative Toxicogenomics Database</a>
<ul>
<li class="chapter" data-level="" data-path="comparative-toxicogenomics-database.html"><a href="comparative-toxicogenomics-database.html#introduction-to-training-module-30"><i class="fa fa-check"></i>Introduction to Training Module</a></li>
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