This reposity contains the main analysis code to perform cross-ancestry meta-analysis as part of the manuscript "Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms"
Scripts are listed by the order in the methods section of the manuscript:
- 1: Cross-ancestry GWAS meta analysis
- 2: Genetic architecture analysis
- 3: Shared genetic analysis
- 4: Genome wide fine mapping
- 5: Multi-omics QTL analysis (SMR)
- 6: Spatial enrichment of heritability
- 7: Cell type specific enrichment
Lulu Shi, Haibin He, Junpeng Li, Kai Gai, Wenjian Li, Yu Zhao, Huijun Yuan, Yang Wu. Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms. Nat Commun (2026). 10.1038/s41467-026-69894-z
For questions, please email us at Lulu Shi (shilulu@stu.wchscu.cn) or Yang Wu (yang.wu@wchscu.edu.cn)