MitoNuclearCOEXPlorer

• The MitoNuclearCOEXPlorer tool allows exploration of relationships between target gene(s) of nuclear origin and the mitochondrial genome
• Levaraging transcriptomic data from the GTEx project, nuclear-mitochondrial co-ordination was quantified by correlating expression levels of nDNA- and mtDNA-encoded genes
• The rationale here being that co-expressed genes may be directly regulating each other, controlled by the same regulatory regime, functionally related, members of the same pathway or part of the same protein complex, and as such, the correlation of their expression is meaningful
• See the MitoNuclearCOEXPlorer tool for analyses options offered and example outputs

Description

This repository contains the User Interface (UI) code for the MitoNuclearCOEXPlorer platform and accompanying back-end functions.

Getting Started

The tool can be reached here: MitoNuclearCOEXPlorer

Related publication

Find the associated publication here

Developers

• Aine Fairbrother-Browne - UI and backend developer
  • Get in touch with Aine at aine.fairbrother-browne.18@ucl.ac.uk.
• Sonia García-Ruiz - UI developer
  • Get in touch with Sonia at s.ruiz@ucl.ac.uk.

Acknowledgments

All members of:

• Ryten Lab
• Hodgkinson Lab