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bluenote-1577 authored Dec 12, 2023
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2. **Precise species-level profiling**: Our tests show that sylph is more precise than Kraken and about as precise and sensitive as marker gene methods (MetaPhlAn, mOTUs).

3. **Ultrafast, multithreaded, multi-sample**: sylph is > 100x faster than MetaPhlAn for multi-sample processing. sylph only takes 13GB of RAM for profiling against the entire GTDB-R214 database (85k genomes).
3. **Ultrafast, multithreaded, multi-sample**: sylph can be > 100x faster than MetaPhlAn for multi-sample processing. sylph only takes 13GB of RAM for profiling against the entire GTDB-R214 database (85k genomes).

4. **Easily customized databases**: sylph does not require taxonomic information, so you can profile against [metagenome-assembled genomes (MAGs), viruses, eukaryotes](https://github.com/bluenote-1577/sylph/wiki/Pre%E2%80%90built-databases), even assembled contigs, etc. Taxonomic information can be incorporated downstream for traditional profiling reports.

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