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Merge pull request #115 from bendichter/patch-4
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fix typos for fmri-preprocessing-tutorial.md
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anibalsolon authored Feb 26, 2024
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### 1. Anatomical preprocessing.

The first step of diffusion preprocessing often involves processing the anatomical images. In order to guarantee that any generalizations regarding location made from the preprocessed diffusion data is anatomically-informed, we must have both of our anatomical (T1w or T2w) images and our diffusion MRI images **aligned**. One way we can make this easier for [fMRIPrep](https://brainlife.io/app/5c61c69f14027a01b14adcb3) is by aligning the anatomical images in such a way that the center of the brain is centered in the image. We refer to this as **ACPC-aligned**, as we are aligning the data to the **anterior commissure-posterior comissure plane**. This is the first step in fMRI preprocessing, and it is typically done with the [FSL Anat (T1w)](https://brainlife.io/app/5e3c87ae9362b7166cf9c7f4) app. Once we've centered our anatomical image, we can move onto functional MRI preprocessing.
The first step of diffusion preprocessing often involves processing the anatomical images. In order to guarantee that any generalizations regarding location made from the preprocessed diffusion data is anatomically-informed, we must have both of our anatomical (T1w or T2w) images and our diffusion MRI images **aligned**. One way we can make this easier for [fMRIPrep](https://brainlife.io/app/5c61c69f14027a01b14adcb3) is by aligning the anatomical images in such a way that the center of the brain is centered in the image. We refer to this as **ACPC-aligned**, as we are aligning the data to the **anterior commissure-posterior comissure plane**. This is the first step in fMRI preprocessing, and it is typically done with the [FSL Anat (T1)](https://brainlife.io/app/5e3c87ae9362b7166cf9c7f4) app. Once we've centered our anatomical image, we can move onto functional MRI preprocessing.


### 2. Functional preprocessing.
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Useful information about fMRIPrep anatomical preprocessing can be found in this [original Nature paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319393/#S13title).

There are two versions of the brainlife.io fMRIPrep app. One generates outputs mapped to the volumes ([fMRIPrep-volume](https://brainlife.io/app/5c61c69f14027a01b14adcb3)) and the other generates outputs mapped to the surfaces ([fMRIPrep-surface](https://brainlife.io/app/5dfceebd32bff0640ce27bbd)).

For this tutorial, we will use the volume-based version.
There are two versions of the brainlife.io fMRIPrep app. One generates outputs mapped to the volumes ([fMRIPrep-volume](https://brainlife.io/app/5c61c69f14027a01b14adcb3)) and the other generates outputs mapped to the surfaces ([fMRIPrep-surface](https://brainlife.io/app/5dfceebd32bff0640ce27bbd)). For this tutorial, we will use the volume-based version.

Now, let's get to work! The following steps of this tutorial will show you how to:

1. preprocess the anatomical (T1w & T2w) data using FSL
2. generate anatomical surfaces using Freesurfer,
3. preprocess the fMRI data using fMRIPrep
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1. On the 'Submit App' page, select the following:
* For input, select the staged preprocessed, 'acpc_aligned'-tagged anatomical (T1w & T2w) images by clicking the drop-down menu and finding the appropriate datasets.
* Select the boxes for 'hippocampal' and 'thalamicnuclei'. Leave all other defaults the same
![Free Surfer Options](../img/fmri_prep_tutorial_free_surfer_options.png)

![Free Surfer Options 1](../img/fmri_prep_tutorial_free_surfer_options_1.png)

![Free Surfer Options 2](../img/fmri_prep_tutorial_free_surfer_options_2.png)
![Freesurfer Options](../img/fmri_prep_tutorial_free_surfer_options.png)
![Freesurfer Options 1](../img/fmri_prep_tutorial_free_surfer_options_1.png)
![Freesurfer Options 2](../img/fmri_prep_tutorial_free_surfer_options_2.png)
* Select the box for 'Archive all output datasets when finished'
* For 'Dataset Tags,' type and enter 'fsl_anat'
* Hit 'Submit'
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