Merge pull request #63 from cBioPortal/validate_germline

Validation Update: Add a warning for GERMLINE variants in MAF and SV files
cBioPortal · Oct 21, 2024 · fb81dc6 · fb81dc6
2 parents 2efc058 + 467c80d
commit fb81dc6
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Showing 3 changed files with 41 additions and 18 deletions.
diff --git a/scripts/importer/validateData.py b/scripts/importer/validateData.py
@@ -2397,6 +2397,9 @@ def checkMutationStatus(self, value):
         if value.lower() not in ['none', 'germline', 'somatic', 'loh', 'post-transcriptional modification', 'unknown', 'wildtype'] and value != '':
             self.logger.warning('Mutation_Status value is not in MAF format',
                                 extra={'line_number': self.line_number, 'cause': value})
+        if value.lower() == 'germline':
+            self.logger.warning('GERMLINE variant identified from the Mutation_Status value. If this variant is not meant for public release, please remove it.',
+                                extra={'line_number': self.line_number, 'cause': value})
         return True
 
 class ClinicalValidator(Validator):
@@ -3216,6 +3219,10 @@ def checkSVstatus(sv_status):
             if sv_status is None:
                 self.logger.warning('No value in SV_Status, assuming the variant is SOMATIC',
                                   extra={'line_number': self.line_number})
+            elif sv_status.lower() == 'germline':
+                self.logger.warning('GERMLINE variant identified from the SV_Status value. If this variant is not meant for public release, please remove it.',
+                                  extra={'line_number': self.line_number,
+                                         'cause': sv_status})
             else:
                 if not sv_status.lower() in ['somatic', 'germline']:
                     self.logger.error('Invalid SV_Status value: possible values are [SOMATIC, GERMLINE]',