an interactive explorer for single-cell transcriptomics data

CZ CELLxGENE Annotate (pronounced "cell-by-gene") is an interactive data explorer for single-cell datasets, such as those coming from the Human Cell Atlas. Leveraging modern web development techniques to enable fast visualizations of at least 1 million cells, we hope to enable biologists and computational researchers to explore their data.

Whether you need to visualize one thousand cells or one million, CELLxGENE Annotate helps you gain insight into your single-cell data.

Getting started

The comprehensive guide to CZ CELLxGENE Annotate

The CZ CELLxGENE Annotate documentation is your one-stop-shop for information about CELLxGENE Annotate! You may be particularly interested in:

• Seeing what Annotate can do
• Learning more about Annotate installation and usage
• Preparing your own data for use in Annotate
• Checking out our roadmap for future development
• Contributing to Annotate

Quick start

To install CELLxGENE Annotate you need Python 3.10+. We recommend installing Annotate into a conda or virtual environment.

Install the package.

pip install cellxgene

Launch Annotate with an example anndata file

cellxgene launch https://cellxgene-example-data.czi.technology/pbmc3k.h5ad

To explore more datasets already formatted for Annotate, check out the Demo data or see Preparing your data to learn more about formatting your own data for CELLxGENE Annotate.

Supported browsers

CELLxGENE Annotate currently supports the following browsers:

• Google Chrome 61+
• Edge 15+
• Firefox 60+

Please file an issue if you would like us to add support for an unsupported browser.

Finding help

We'd love to hear from you! For questions, suggestions, or accolades, join the #cellxgene-users channel on the CZI Science Community Slack and say "hi!".

For any errors, report bugs on Github.

Developing with CZ CELLxGENE Annotate

Contributing

We warmly welcome contributions from the community! Please see our contributing guide and don't hesitate to open an issue or send a pull request to improve CELLxGENE Annotate. Please see the dev_docs for pull request suggestions, unit test details, local documentation preview, and other development specifics.

This project adheres to the Contributor Covenant code of conduct. By participating, you are expected to uphold this code. Please report unacceptable behavior to opensource@chanzuckerberg.com.

Reuse

This project was started with the sole goal of empowering the scientific community to explore and understand their data. As such, we encourage other scientific tool builders in academia or industry to adopt the patterns, tools, and code from this project. All code is freely available for reuse under the MIT license.

Before extending CELLxGENE Annotate, we encourage you to reach out to us with ideas or questions. It might be possible that an extension could be directly contributed, which would make it available for a wider audience, or that it's on our roadmap and under active development.

See the CELLxGENE extensions section of our documentation for examples of community use and CELLxGENE extensions.

Security

If you believe you have found a security issue, we would appreciate notification. Please send email to security@chanzuckerberg.com.

Inspiration

We've been heavily inspired by several other related single-cell visualization projects, including the UCSC Cell Browser, Cytoscape, Xena, ASAP, GenePattern, and many others. We hope to explore collaborations where useful as this community works together on improving interactive visualization for single-cell data.

We were inspired by Mike Bostock and the crossfilter team for the design of our filtering implementation.

We have been working closely with the scanpy team to integrate with their awesome analysis tools. Special thanks to Alex Wolf, Fabian Theis, and the rest of the team for their help during development and for providing an example dataset.

We are eager to explore integrations with other computational backends such as Seurat or Bioconductor