MAGNET_GX

R script that imports a transcriptomics dataset (https://www.med.upenn.edu/magnet/) and exports an annotated data file that is suitable for downstream biological analysis, such as pathway and network analysis.
The dataset is an RNA-sequencing dataset from the MAGNet consortium. To generate this dataset, left ventricular free-wall tissue was harvested at the time of cardiac surgery from subjects with heart failure undergoing transplantation and from unused donor hearts with apparently normal function. This dataset is a spectacular resource of left ventricular transcriptomes of non-failing healthy donors, Peripartum cardiomyopathy (PPCM), Hypertrophic cardiomyopathy (HCM) and Dilated cardiomyopathy (DCM) patients. Next to the RNA-sequencing data (in log2-transformed CPM values), limited sample information is available (age, sex, ethnicity, disease state).

MSB1005 - Experimental Design & Data Managment
Final assignment

Author

Giorgia Del Missier
i6292403

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Cardiac Energy Metabolism Analysis

Understanding sex-related differences in cardiac energy metabolism through genome-scale metabolic models in patients with dilated cardiomyopathy
PRO4002 - Final assignment

Authors

Giorgia Del Missier
Hannah Schultheiß
Michal Skawinski
Xenia Sterl