PBPK Modeling For Therapeutic Nanoparticles Loaded With Drug
This repository includes the model reproduced from the the paper and datasets from figures and the supplementary materials:
Shalgunov et al. Comprehensive study of the drug delivery properties of poly(l-lactide)-poly(ethylene glycol) nanoparticles in rats and tumor-bearing mice. 2017 Journal of Controlled Release 261. DOI: 10.1016/j.jconrel.2017.06.006
- "Units inconsistency" messages for some records:
v,vrelbecause of limited support of fractional units in Heta. But this doesn't affect simulation results.
Simulated vs measured dependence of average VCR concentration for the NP of type U16c.
You find other diagnostic plots in the directory /diagnostics/reproduced model/
See dist branch
- Simulations and experimental data in HetaSimulator
- Share the datasets
- Reproduce fitting
Evgeny Metelkin is the author of the Heta-based modeling code.
The model and data in the study were reproduced from the published study. The authors of the original study are: V. Shalgunov, D. Zaytseva-Zotova, A. Zintchenko, T. Levada, Y. Shilov, D. Andreyev, D. Dzhumashev, E. Metelkin, A. Urusova, O. Demin, K. McDonnell, G. Troiano, S. Zale, E. Safarovа