META EDC

Metformin treatment in Africa - META

• https://www.ucl.ac.uk/global-health/research/z-research/respond-africa/metformin-treatment-africa-meta
• https://www.inteafrica.org/related-projects/meta-trial/
• https://www.lstmed.ac.uk/research/departments/international-public-health/respond-africa/meta
• http://www.isrctn.com/ISRCTN76157257

py 3.12+ / DJ 5.2 using the Clinic EDC framework

This codebase is used for two randomized clinical trials:

---

META PHASE II:

(final version 0.1.77)

Metformin Treatment for Diabetes Prevention in Africa: META Trial TASO, MRC/UVRI/LSHTM, NIMR – TZ and Liverpool School of Tropical Medicine (ISRCTN76157257) http://www.isrctn.com/ISRCTN76157257

---

META PHASE III:

A randomised placebo-controlled double-blind phase III trial to determine the effects of metformin versus placebo on the incidence of diabetes in HIV-infected persons with pre-diabetes in Tanzania.

Liverpool School of Tropical Medicine

EDCTP grant number: RIA2018CO-2513

Trial registration: ISCRTN 77382043

https://ico.org.uk/ESDWebPages/Entry/Z4763134

---

See also https://github.com/clinicedc/edc

Installation

As of version 1.1.10, we are building and deploying with uv.

Here we assume you have your DB setup and already have your .env file.

First-time install

Assuming you are logged into the account myaccount:

mkdir -p ~/.etc/meta && \
mkdir ~/edc && \
cd ~/edc && \
uv venv && \
uv pip install -U meta-edc==1.1.10 && \
wget https://raw.githubusercontent.com/meta-trial/meta-edc/1.1.10/manage.py && \
uv pip freeze | grep meta-edc

Copy your .env file to ~/.etc.

Place this at or near the end of your .bashrc:

# >>> EDC using uv >>>
export DJANGO_SETTINGS_MODULE=meta_edc.settings.uat
export META_PHASE=3
export DJANGO_BASE_DIR=/home/myaccount/edc
export DJANGO_ENV_DIR=/home/myaccount/.etc/
cd ~/edc
source .venv/bin/activate
export PATH="/home/myaccount/edc:$PATH"
# <<< EDC using uv <<<

Source .bashrc and run manage.py check.

source ~/.bashrc && \
cd ~/edc && \
python manage.py check

If all is OK, run migrate:

Explicitly specify the settings file when using migrate.

• live: --settings=meta_edc.settings.live
• uat: --settings=meta_edc.settings.uat
• debug: --settings=meta_edc.settings.debug

cd ~/edc && \
python manage.py migrate --settings=meta_edc.settings.live

Update an existing install

From the above example:

cd ~/edc && \
uv venv --clear && \
uv pip install -U meta-edc==1.1.10 && \
wget -O manage.py https://raw.githubusercontent.com/meta-trial/meta-edc/1.1.10/manage.py && \
uv pip freeze | grep meta-edc && \
python manage.py check

If all is OK, run migrate

cd ~/edc && \
python manage.py migrate --settings=meta_edc.settings.live