Modeling of published clinical Cimetidine-Metformin-DDI studies for model evaluation
Within this repository, we share a PK-Sim project file containing simulations of all published clinical studies used to evaluate the predictive performance of our models regarding the Cimetidine-Metformin-DDI, including the respective observed data. For further details and documentation please refer to [1].
PK-Sim Version V11.
The model is distributed under the GPLv2 License.
[1] Hanke N, Türk D, Selzer D, Ishiguro N, Ebner T, Wiebe S, Müller F, Stopfer P, Nock V, Lehr T. A Comprehensive Whole‑Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals. Clinical Pharmacokinetics 2020, https://doi.org/10.1007/s40262-020-00896-w