Formatting

poster.Rmd

@@ -2,26 +2,21 @@
 poster_height: 46in
 poster_width: 33in
 
-title: "Structural cerebellar connectivity in schizophrenia: Support for the cognitive dysmetria theory"
+title: "Structural cerebellar connectivity in schizophrenia"
 author:
   - name: Teresa Gomez
     affil: 1
     orcid: '0000-0001-7909-4430'
   - name: Sivan Jossinger
     affil: 2
-    orcid: '0000-0000-0000-0000'
   - name: John Kruper
     affil: 1
-    orcid: '0000-0000-0000-0000'
   - name: Adam Richie-Halford
     affil: 3
-    orcid: '0000-0000-0000-0000'
   - name: Michal Ben-Shachar
     affil: 2
-    orcid: '0000-0000-0000-0000'
   - name: Jason Yeatman
     affil: 3
-    orcid: '0000-0000-0000-0000'
   - name: Ariel Rokem
     affil: 1
     orcid: '0000-0003-0679-1985'
@@ -41,7 +36,7 @@ titletext_fontfamily: "palatino"
 
 output:
   posterdown::posterdown_html:
-    self_contained: true
+    self_contained: no
     pandoc_args: ["--csl=science-without-titles.csl"]
 
 header-includes:
@@ -59,8 +54,9 @@ knit: pagedown::chrome_print
 }
 
 body {
-bottom-margin: 0px;
+    bottom-margin: 0px;
 }
+
 .poster_body h1 {
     background-color: #b7a57a;
     border: #85754d;
@@ -72,7 +68,6 @@ h5 br {
 
 .poster_title h3 {
     font-family: "Palatino", "URW Palladio L", "serif";
-
 }
 
 .poster_title h5 {
@@ -82,7 +77,7 @@ h5 br {
 }
 
 .title_container {
-    height: 165mm; }
+    height: 180mm; }
 
 img[src*='#logo'] {
     width: 10%;
@@ -102,36 +97,44 @@ knitr::opts_chunk$set(echo = FALSE)
 - Previous research found increased functional connectivity in the cerebello-thalamo-cortical circuits in individuals at clinical high risk for psychosis. [@Cao2018]
 - This hyperconnectivity was more pronounced in individuals who converted to psychosis, correlated to the severity of symptoms, and was predictive of the time to conversion.
 
-![The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas… The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle. [@Palesi2015-oi]](images/palesi.jpg){#id .class width=100% height=100% }
+<center>
+
+![The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas… The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle. [@Palesi2015-oi]](images/palesi.jpg){width=60% height=60%}
+
+</center>
 
 **QUESTION**: Are the physical properties of the white matter tracts of the CTC different in individuals with SZ?   
 
+\
+
 # Methods
 
-- **Data:** the UCLA Consortium for Neuropsychiatric Phenomics LA5c Study [@ds000030:1.0.0], which includes diffusion MRI (dMRI) data from 49 participants with SZ (mean age: 36.2 +/- 8.8 SD; 12 female), 40 participants with ADHD (mean age: 31.95 +/- 10.3 SD; 20 female), 49 participants with bipolar disorder (BP) (mean age: 35.3 +/- 9.0 SD, 21 female), and 123 controls (CTRL) (mean age: 31.6 +/- 8.8 SD; 58 female).
+- **Data:** the UCLA Consortium for Neuropsychiatric Phenomics LA5c Study [@ds000030:1.0.0], which includes diffusion MRI (dMRI) data from 49 participants with SZ (mean age: 36.2 +/- 8.8 SD; 12 female), 40 participants with ADHD (mean age: 31.95 +/- 10.3 SD; 20 female), 49 participants with bipolar disorder (BD) (mean age: 35.3 +/- 9.0 SD, 21 female), and 123 controls (CTRL) (mean age: 31.6 +/- 8.8 SD; 58 female).
 - The data were processed using QSIPREP [@Cieslak2021-vj] and pyAFQ [@Kruper2021-az] [@Yeatman2012-ze]
 - The SCPs were identified in each individual using pyAFQ and anatomical criteria that capture the decussation of these bundles. [@Jossinger2023-gj]
 - This resulted in tract profiles of fractional anisotropy (FA) and mean diffusivity (MD) in each white matter pathway (100 nodes each). 
 - We then fit generalized additive models (GAMs) for FA and MD in each bundle as a function of diagnosis (entered as a factor: SZ or CTRL), nodeID (modeled with an adaptive smooth, where degree of the smooth is determined as the k that minimizes the AIC), age, sex (entered as a factor) and data quality (quantified as the neighbor correlation from QSIPREP). [@Muncy2022GAMs]
 
-<!---
-![](images/OHBM-SZ-SCP-methods.png){#id .class width=100% height=100% }
--->
+![](images/SCP_right.png){width=24% height=24%}
+![](images/SCP_back.png){width=24% height=24%} 
+![](images/SCP_left.png){width=24% height=24%} 
+![](images/SCP_top.png){width=24% height=24%}
+<div style="font-size:32px; font-family:'Palatino'; text-align:center">The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal, coronal and axial anatomical views of the T1-weighted scan of this individual.</div>
 
-![a](images/sub-50010_SCP_right.png){#id .class width=25% height=25% }
-![b](images/sub-50010_SCP_back.png){#id .class width=25% height=25% }
-![c](images/sub-50010_SCP_top.png){#id .class width=25% height=25% }
-![d](images/sub-50010_SCP_left.png){#id .class width=25% height=25% }
-The left (dark blue) and right (light blue) SCP bundles visualized in an individual with SZ, with sagittal (a, d), coronal (b) and axial (c) anatomical views of the T1-weighted scan of this individual. 
+\
+\
+\
 
 # Results
 
-- MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and CTRL groups (p<0.05), but not between the ADHD and CTRL groups or BP and CTRL groups. 
+![](images/figure_mod.png){width=100% height=100%}
+
+- MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and CTRL groups (p<0.05), but not between the ADHD and CTRL groups or BD and CTRL groups. 
 - Individuals with SZ had lower MD in this tract than the matched controls. 
 - This finding held after adding medication as a covariate (haloperidol equivalent dosage). 
 - No other significant differences were found.
 
-![](images/figure.png){#id .class width=100% height=100% }
+\
 
 # Conclusions
 
@@ -141,9 +144,12 @@ The left (dark blue) and right (light blue) SCP bundles visualized in an individ
 - These results appear in line with previous fMRI results that found increased functional connectivity in the CTC in individuals with SZ. [@Cao2018]
 - This provides additional support for the cognitive dysmetria theory of SZ. 
 
+\
 
 # Acknowledgements
 
 NIMH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem), EB027585 (PI: Garyfallidis)
 
+\
+
 # References

references.bib

@@ -203,7 +203,6 @@ @dataset{ds000030:1.0.0
                Freimer, N and Congdon, E and Karlsgodt, K and Sabb, F",
   title     = "UCLA Consortium for Neuropsychiatric Phenomics LA5c Study",
   year      =  2020,
-  doi       = "10.18112/openneuro.ds000030.v1.0.0",
   publisher = "OpenNeuro",
 }
 @ARTICLE{Cieslak2021-vj,