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A method to estimate the proportion of variance explained by heritability and gene-by-environment interactions, in a fast, accurate, efficient, and unbiased manner on biobank-scale datasets (N>300,000).
A method to estimate rare variant heritability. Its versatility lies in the ability to estimate both gene-level and exome-wide heritability, in a fast, accurate, and unbiased manner.
A methodological framework to conduct a calibrated gene-based rare variant association test by leveraging the genome aggregation database (gnomAD) as an external control dataset