Our Joint Research Unit’s main goal is to understand the role of epigenetic mechanisms governing cellular fate, with a particular emphasis on the maintenance of pluripotency, neuronal and muscular differentiation, misregulations of epigenetic mechanisms in cancers, neurodevelopmental diseases and stress responses
Our teams investigate the impact of DNA methylation, histone modifications translation control and non-coding RNA machineries on physiological processes and diseases. Our projects leads us to actively produce, store and analyse high throughput datasets. We are actively developing tools and methods to analyse and integrate these vast amounts of data from mutli-omics datasets. Many teams are also involved in collaborations with physicists and study the effects of mechanical constraints and how the epigenome is contributing to mechano-transduction.