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Deep Learning HW2

This project addresses two learning problems defined in the course assignment

BloodMNIST image classification

Train convolutional neural networks to classify blood cell images from the BloodMNIST dataset.

  • 8 classes, images resized to 3×28×28.
  • Models are trained with Adam and CrossEntropy loss for 200 epochs.
  • Compare behaviour with and without Softmax on the output layer.
  • Add max-pooling layers and measure the impact on accuracy and runtime.
  • Report training loss and validation/test accuracy over epochs.

The goal is to study architectural choices in small CNNs and their effect on performance and efficiency.

RNA-RBP binding affinity prediction (RBFOX1)

Predict continuous binding affinity between RNA sequences and the RNA-binding protein RBFOX1.

  • Input: one-hot encoded RNA sequences from the RNAcompete dataset.
  • Output: normalized fluorescence intensity.
  • Task is regression with masked MSE loss.
  • Evaluation metric is Spearman rank correlation.

Work includes:

  • Implementing and comparing two different neural architectures.
  • Extending one architecture with attention and analysing its effect.
  • Designing a conceptual extension to handle multiple RNA-binding proteins.

The task focuses on learning data-driven approximations of RNA-protein binding preferences rather than explicit biophysical or combinatorial modelling.

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BloodMNIST image classification and RBFOX1 RNA–protein binding affinity prediction (multiple model architectures + attention)

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