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Update 04.from-single-genes-to-gene-networks.md
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How to Cite This Article
Boyle EA, Li YI, Pritchard JK. The Omnigenic Model: Response from the Authors. J Psychiatry Brain Sci. 2017; 2(5): S8; https://doi.org/10.20900/jpbs.20170014S8
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msubirana committed Oct 10, 2024
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Expand Up @@ -48,7 +48,7 @@ The model suggests that most genetic effects arise from these peripheral genes,
[@doi:10.1016/j.cell.2018.05.051].
Trans effects occur when a genetic variant at one locus affects the expression of genes at distant loci, often on different chromosomes.
This contrasts with cis effects, where variants influence genes in their immediate vicinity.
In this context, understanding *trans* effects is crucial for grasping the indirect influence of peripheral genes on core traits [@doi:10.20900/jpbs.20170014S2].
In this context, understanding *trans* effects is crucial for grasping the indirect influence of peripheral genes on core traits [@doi:10.20900/jpbs.20170014S8].

However, the study of trans effects has inherent challenges.
One of the primary limitations is their typically small effect sizes, which makes their detection difficult compared to cis effects.
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