Update content/03.single-variant-single-gene-approaches.md

content/03.single-variant-single-gene-approaches.md

@@ -32,9 +32,6 @@ A simple strategy to link GWAS-associated variants with a gene is by physical pr
 Approaches like MAGMA [@doi:10.1371/journal.pcbi.1004219] are based on proximity to compute a gene-trait association.
 However, SNPs can have distal effects on the expression of the target gene [@doi:10.1126/science.aaz1776; @doi:10.1126/science.1222794; @doi:10.1038/nature13138; @doi:10.1073/pnas.112212199].
 
-The paragraph is well-written and requires minimal corrections.
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 Recent approaches combine multi-omics data from various cell types and tissues with GWAS to identify potential mechanisms of SNPs and the associated genes through molecular quantitative trait loci (molQTLs) [@doi:10.1016/j.molmed.2019.10.004] (Figure {@fig:fig1}).
 For example, an expression quantitative trait locus (eQTL) is a genetic region associated with the expression levels of a nearby or distant gene [@doi:10.1016/j.jgg.2023.05.003].
 eQTL studies estimate that the majority of heritability is explained by the combination of multiple weak *trans*-eQTLs [@doi:10.1038/s41588-021-00913-z].