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template: post.html | ||
title: Data model and plotting update | ||
description: Now with "high level" support | ||
date: 2024-07-02 | ||
links: | ||
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![Example Plot](/img/high-level-EGFR-glioblastoma-example-plot.svg){ style="" } | ||
Both the data model and the plot engine now support an separate color style for | ||
high level CNV events. In histograms those are overplotted on the standard | ||
color scheme - e.g. red areas where high level plots were detected, by their | ||
absolute frequency. In the example plot above we performed a search for high-level | ||
gains involving EGFR, in glioblastomas, and then only plotted chromosomes 7 and 9. | ||
While the ~100% peak at EGFR is expected, additionally nearly 70% of the matched | ||
samples have a focal and high level deletion involving the CDKN2A locus. | ||
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