Masked Autoencoders are Scalable Learners of Cellular Morphology

Official repo for Recursion's two recently accepted papers:

• Spotlight full-length paper at CVPR 2024 -- Masked Autoencoders for Microscopy are Scalable Learners of Cellular Biology
  • Paper: https://arxiv.org/abs/2404.10242
  • CVPR poster page with video: https://cvpr.thecvf.com/virtual/2024/poster/31565
• Spotlight workshop paper at NeurIPS 2023 Generative AI & Biology workshop
  • Paper: https://arxiv.org/abs/2309.16064

Provided code

See the repo for ingredients required for defining our MAEs. Users seeking to re-implement training will need to stitch together the Encoder and Decoder modules according to their usecase.

Furthermore the baseline Vision Transformer architecture backbone used in this work can be built with the following code snippet from Timm:

import timm.models.vision_transformer as vit

def vit_base_patch16_256(**kwargs):
    default_kwargs = dict(
        img_size=256,
        in_chans=6,
        num_classes=0,
        fc_norm=None,
        class_token=True,
        drop_path_rate=0.1,
        init_values=0.0001,
        block_fn=vit.ParallelScalingBlock,
        qkv_bias=False,
        qk_norm=True,
    )
    for k, v in kwargs.items():
        default_kwargs[k] = v
    return vit.vit_base_patch16_224(**default_kwargs)

Provided models

A publicly available model for research can be found via Nvidia's BioNemo platform, which handles inference and auto-scaling: https://www.rxrx.ai/phenom

We have partnered with Nvidia to host a publicly-available smaller and more flexible version of the MAE phenomics foundation model, called Phenom-Beta. Interested parties can access it directly through the Nvidia BioNemo API:

• https://blogs.nvidia.com/blog/drug-discovery-bionemo-generative-ai/
• https://www.youtube.com/watch?v=Gch6bX1toB0