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agudys authored Oct 16, 2024
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# LZ-ANI

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LZ-ANI is a fast and memory-efficient tool for determining average nucleotide identity (ANI) in large sets of genomic sequences. The tool uses Lempel-Ziv parsing, achieving high sensitivity in discerning matched and mismatched nucleotides, thereby enabling accurate determination of ANI. Its efficiency stems from a simplified indel handling model, making LZ-ANI magnitudes faster than alignment-based tools (e.g., BLASTn, MegaBLAST) while maintaining accuracy comparable to the most sensitive BLASTn searches.
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