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@scbirlab

SCBIR Lab

README.md

Systems Chemical Biology of Infection and Resistance Laboratory

Logo of SCBIR lab

The SCBIR lab is based the Francis Crick Institute in London. We use large-scale genetics and chemical biology to study how pathogenic bacteria infect and evolve resistance to antibiotics.

Ultimately, we aim to enable antimicrobial therapies which exploit key weaknesses in the ability of pathogenic bacteria to infect and evolve resistance to antibiotics.

Our work focuses on these areas (click the links for more information):

Find out more about our research here!

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  1. hts-tools hts-tools Public

    🏮 Parsing and analysing platereader absorbance and fluorescence data.

    Python 1

  2. schemist schemist Public

    ⬢⬢⬢ Organizing and processing tables of chemical structures.

    Python 1

  3. yunta yunta Public

    🍐 Predicting protein-protein interactions and structures from multiple sequence alignments.

    Python 1

  4. crispio crispio Public

    🌱 Designing CRISPRi experiments in bacteria

    Python

  5. lchemme lchemme Public

    🚄 Training and applying large chemistry models for embeddings.

    Python

  6. duvida duvida Public

    🧐 Calculating exact and approximate confidence and information metrics for deep learning on general purpose and chemistry tasks.

    Python

Repositories

Showing 10 of 26 repositories
  • yunta Public

    🍐 Predicting protein-protein interactions and structures from multiple sequence alignments.

    scbirlab/yunta’s past year of commit activity
    Python 1 0 0 0 Updated Apr 10, 2025
  • nf-sbrnaseq Public

    ➡️🦠🧬 Nextflow pipeline to process demultiplexed Illumina paired-end FASTQ files from multiple bacterial samples into a gene x cell count table.

    scbirlab/nf-sbrnaseq’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Apr 9, 2025
  • duvida Public

    🧐 Calculating exact and approximate confidence and information metrics for deep learning on general purpose and chemistry tasks.

    scbirlab/duvida’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Apr 6, 2025
  • lchemme Public

    🚄 Training and applying large chemistry models for embeddings.

    scbirlab/lchemme’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Mar 24, 2025
  • crispio Public

    🌱 Designing CRISPRi experiments in bacteria

    scbirlab/crispio’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Mar 13, 2025
  • schemist Public

    ⬢⬢⬢ Organizing and processing tables of chemical structures.

    scbirlab/schemist’s past year of commit activity
    Python 1 MIT 0 0 0 Updated Mar 4, 2025
  • carabiner Public

    🪨 Useful python utilities.

    scbirlab/carabiner’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Mar 1, 2025
  • nf-inspect Public

    ➡️🧬🔍 Nextflow pipeline to process demultiplexed Illumina paired-end FASTQ files from INSPECT experiments.

    scbirlab/nf-inspect’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Feb 27, 2025
  • nf-crispriseq Public

    ➡️🧫 Calculate fitness from massive competition experiments using CRISPRi-seq.

    scbirlab/nf-crispriseq’s past year of commit activity
    Nextflow 0 MIT 0 0 0 Updated Feb 25, 2025
  • ogilo Public

    ⛓️ Automating construction of oligo library sequences for oligo array synthesis.

    scbirlab/ogilo’s past year of commit activity
    Python 0 MIT 0 0 0 Updated Feb 19, 2025
View all repositories

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