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Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease.

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Effect of APOE Alleles on the Glial Transcriptome in Normal Aging and Alzheimer's Disease

We investigated the differential effects of APOE alleles on the microglia and astrocyte transcriptome in the absence and presence of neuritic plaques (NPs) using bulk brain RNA-seq data from two large brain banks and performed follow-on experiments in APOE knock-in mice.

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To read our documented code, please visit mindds.github.io/apoe-glia or see below.

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qPCR Analysis

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Effect of APOE alleles on the glial transcriptome in normal aging and Alzheimer’s disease.

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