drug-discovery motion-tracking alzheimer-disease-prediction adaptive-thresholding morphology-analysis amyotrophic-lateral-sclerosis size-and-position morphology-metrics scale-space-filtering induced-pluripotent-stem-cells scale-space-feature-detection hessian-matrices patient-derived-cells stationary-wavelet-transform mitochondria-axons secondary-assay functional-assay kimograph-analysis axonal-transport trajectory-reconstruction