PharmacoDB unites multiple drug sensitivity databases. A REST API is available and interfaces to some basic endpoints are provided in this package. We also provide some basic support for working with the Cell Line Ontology and ChEBI.
A basic purpose of this package is to support exploration of the completeness and utility of available ontologies for cell lines and drugs. A relevant study of the possibility of "drug set enrichment analysis" has been published by Napolitano and colleagues.
We note that detailed RESTful interrogation of many ontologies
is supported by the r Biocpkg("rols") package. In the long
run we would like to make use of the EBI Ontology Lookup System
as a central resource of this package, but to develop concepts
at these early stages, static images of ontologies are employed.
pogos can be installed using Bioconductor. Be sure BiocManager has been installed from CRAN. Then:
BiocManager::install("pogos")
will take care of all dependencies.
Use the "Get started" tab above to learn more.