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24 changes: 12 additions & 12 deletions manuscript.html
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<meta name="author" content="Alexandra J. Lee" />
<meta name="author" content="Beth Signal" />
<meta name="author" content="Juan Jose Carmona" />
<meta name="dcterms.date" content="2021-01-23" />
<meta name="dcterms.date" content="2021-01-28" />
<meta name="keywords" content="quick tips, machine learning, deep learning, artificial intelligence" />
<title>Ten Quick Tips for Deep Learning in Biology</title>
<style>
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<meta name="citation_title" content="Ten Quick Tips for Deep Learning in Biology" />
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<meta name="citation_fulltext_html_url" content="https://Benjamin-Lee.github.io/deep-rules/" />
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Expand All @@ -153,10 +153,10 @@ <h1 class="title">Ten Quick Tips for Deep Learning in Biology</h1>
</header>
<p><small><em>
This manuscript
(<a href="https://Benjamin-Lee.github.io/deep-rules/v/cc09f2b48953fe4b7a52ad5ff955bfb0d25e62bd/">permalink</a>)
(<a href="https://Benjamin-Lee.github.io/deep-rules/v/4d338ed6591c956d3195054eb881ed8f11b69a21/">permalink</a>)
was automatically generated
from <a href="https://github.com/Benjamin-Lee/deep-rules/tree/cc09f2b48953fe4b7a52ad5ff955bfb0d25e62bd">Benjamin-Lee/deep-rules@cc09f2b</a>
on January 23, 2021.
from <a href="https://github.com/Benjamin-Lee/deep-rules/tree/4d338ed6591c956d3195054eb881ed8f11b69a21">Benjamin-Lee/deep-rules@4d338ed</a>
on January 28, 2021.
</em></small></p>
<h2 id="authors">Authors</h2>
<p>Please note the current author order is chronological and does not reflect the final order.</p>
Expand Down Expand Up @@ -786,7 +786,7 @@ <h2 class="page_break_before" id="references">References</h2>
<div id="ref-ndSzNxZQ">
<p>29. <strong>apple/turicreate</strong> <br />
Apple<br />
(2021-01-23) <a href="https://github.com/apple/turicreate">https://github.com/apple/turicreate</a></p>
(2021-01-28) <a href="https://github.com/apple/turicreate">https://github.com/apple/turicreate</a></p>
</div>
<div id="ref-ra8TSEHY">
<p>30. <strong>Auto-Keras: An Efficient Neural Architecture Search System</strong> <br />
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- Juan Jose Carmona
bibliography:
- content/manual-references.json
date-meta: '2021-01-23'
date-meta: '2021-01-28'
header-includes: '<!--
Manubot generated metadata rendered from header-includes-template.html.
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<meta property="twitter:title" content="Ten Quick Tips for Deep Learning in Biology" />
<meta name="dc.date" content="2021-01-23" />
<meta name="dc.date" content="2021-01-28" />
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Expand Down Expand Up @@ -258,10 +258,10 @@ title: Ten Quick Tips for Deep Learning in Biology

<small><em>
This manuscript
([permalink](https://Benjamin-Lee.github.io/deep-rules/v/cc09f2b48953fe4b7a52ad5ff955bfb0d25e62bd/))
([permalink](https://Benjamin-Lee.github.io/deep-rules/v/4d338ed6591c956d3195054eb881ed8f11b69a21/))
was automatically generated
from [Benjamin-Lee/deep-rules@cc09f2b](https://github.com/Benjamin-Lee/deep-rules/tree/cc09f2b48953fe4b7a52ad5ff955bfb0d25e62bd)
on January 23, 2021.
from [Benjamin-Lee/deep-rules@4d338ed](https://github.com/Benjamin-Lee/deep-rules/tree/4d338ed6591c956d3195054eb881ed8f11b69a21)
on January 28, 2021.
</em></small>

## Authors
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91 changes: 33 additions & 58 deletions references.json
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"page": "831-840",
"volume": "17",
"issue": "5",
"source": "DOI.org (Crossref)",
"URL": "https://doi.org/f89ms7",
"DOI": "10.1093/bib/bbv082",
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"shortTitle": "Correct machine learning on protein sequences",
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{
"family": "Walsh",
Expand All @@ -3036,37 +3024,25 @@
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9
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"abstract": "Abstract\r\n \r\n Motivation\r\n In the past two decades, scientists in different laboratories have assayed gene expression from millions of samples. These experiments can be combined into compendia and analyzed collectively to extract novel biological patterns. Technical variability, or \"batch effects,\" may result from combining samples collected and processed at different times and in different settings. Such variability may distort our ability to extract true underlying biological patterns. As more integrative analysis methods arise and data collections get bigger, we must determine how technical variability affects our ability to detect desired patterns when many experiments are combined.\r\n \r\n \r\n Objective\r\n We sought to determine the extent to which an underlying signal was masked by technical variability by simulating compendia comprising data aggregated across multiple experiments.\r\n \r\n \r\n Method\r\n We developed a generative multi-layer neural network to simulate compendia of gene expression experiments from large-scale microbial and human datasets. We compared simulated compendia before and after introducing varying numbers of sources of undesired variability.\r\n \r\n \r\n Results\r\n The signal from a baseline compendium was obscured when the number of added sources of variability was small. Applying statistical correction methods rescued the underlying signal in these cases. However, as the number of sources of variability increased, it became easier to detect the original signal even without correction. In fact, statistical correction reduced our power to detect the underlying signal.\r\n \r\n \r\n Conclusion\r\n When combining a modest number of experiments, it is best to correct for experiment-specific noise. However, when many experiments are combined, statistical correction reduces our ability to extract underlying patterns.",
"URL": "https://doi.org/ghhtpf",
"DOI": "10.1093/gigascience/giaa117",
"ISSN": "2047-217X",
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"id": "1GGrbeMvT",
"author": [
{
"family": "Lee",
Expand All @@ -3092,21 +3068,20 @@
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"title": "Correcting for experiment-specific variability in expression compendia can remove underlying signals",
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Expand Up @@ -97,13 +97,13 @@ multilayer
Nuffield
operationalize
overfit
overfitting
Overfitting
overinterpretation
parallelized
perceptrons
pharmacovigilance
phenotypes
Pre
pre
pretraining
pseudorandom
pstew
Expand All @@ -126,7 +126,7 @@ TODO
toolset
TPOT
transformative
translational
Translational
triaged
Triche
Tschira
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