Add DGB2 Appyter

appyters/Drug_Gene_Budger2/README.md

@@ -0,0 +1,11 @@
+# Drug Gene Budger (DGB) 2
+
+This appyter takes a single gene as input and identifies up-regulating and down-regulating drugs from three connectivity mapping resources.
+
+- [Ginkgo GDPx1 and GDPx2 datasets](https://huggingface.co/ginkgo-datapoints)
+
+- [Novartis DRUG-seq U2OS MoABox dataset](https://zenodo.org/records/14291446)
+
+- [LINCS L1000 Chemical Perturbation dataset](https://maayanlab.cloud/sigcom-lincs/#/Download)
+
+In addition to producing tables of ranked up- and down-regulating drugs of the input gene, the notebook creates volcano plot visualizations and UpSet plots that identify overlap in regulators across datasets. 

appyters/Drug_Gene_Budger2/appyter.json

@@ -0,0 +1,31 @@
+{
+    "$schema": "https://raw.githubusercontent.com/MaayanLab/appyter-catalog/main/schema/appyter-validator.json",
+    "name": "Drug_Gene_Budger2",
+    "title": "Drug Gene Budger (DGB) 2",
+    "version": "0.0.1",
+    "description": "An appyter that retrieves drugs that up-regulate and down-regulate a single input gene across Connectivity Mapping datasets",
+    "image": "dgb_logo.png",
+    "authors": [
+        {
+            "name": "Lily Taub",
+            "email": "lilydtaub@gmail.com"
+        }
+    ],
+    "url": "https://github.com/MaayanLab/appyter-catalog",
+    "tags": [
+        "L1000",
+        "DRUG-seq",
+        "RNA-seq"
+    ],
+    "license": "CC-BY-NC-SA-4.0",
+    "public": true,
+    "appyter": {
+        "file": "drug_gene_budger2_appyter.ipynb",
+        "profile": "biojupies",
+        "extras": [
+            "toc",
+            "hide-code",
+            "toggle-code"
+        ]
+    }
+}