GitHub - ModelDBRepository/100603: ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007)

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ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007)

modeldb.science/100603

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Name		Name	Last commit message	Last commit date
Latest commit History 1 Commit
6erg.h		6erg.h
Makefile		Makefile
README.html		README.html
cblock.h		cblock.h
decsol.f		decsol.f
ergout.c		ergout.c
k6erg.c		k6erg.c
kergdriver.c		kergdriver.c
radau5.f		radau5.f
state.data		state.data
voltage.jpg		voltage.jpg

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<html><pre>
The parameters are set to replicate Fig 6D in

Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD. Computational
Model Predicts a Role for ERG in Repolarizing Plateau Potentials in
Dopamine Neurons: Implications for Modulation of Neuronal
Activity. J. Neurophysiol 98:3006-3022. 2007

The output is the time followed by the state variables for voltage,
fraction of activated ERG channels, activation of the calcium channel,
calcium, activation of the H current, and fraction of inactivated of
the ERG channels.

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To run the programs in linux/unix, after extracting the files and
cd'ing to the directory you can type:

make koprisan
./koprisan > output.dat

and then make plots for example with octave

load output.dat
plot (output(:,1),output(:,2))

which shows the voltage time series:

<img src="./voltage.jpg" alt="voltage trace">
</pre></html>