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ahmig committed Oct 19, 2023
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Expand Up @@ -178,7 +178,7 @@ blue line shows the linear model fit.](`r params$fig_cor_snp`){#fig-fig_cor_snp}
### Description for intra-host nucleotide variants

A total of `r n_SNV` different single nucleotide variants (SNV) and `r n_INDELS`
INDELs have been detected along the genome (@fig-SNV).
insertions and deletions (indels) have been detected along the genome (@fig-SNV).

::: {.panel-tabset}

Expand Down Expand Up @@ -225,11 +225,12 @@ frequencies in time for a given genome position.](`r params$panel`){#fig-panel}
### Correlation between alternative alleles

To detect possible interactions between mutations, pairwise correlation between allele
frequencies are calculated and shown in @fig-heatmap. This heatmap is an interactive figure in which it is posible to zoom in specific regions.
frequencies are calculated (@fig-heatmap). The heatmap is an interactive figure that allows
zooming in on specific regions.

```{r heatmap, echo = F, message = F, fig.align = 'center'}
#| label: fig-heatmap
#| fig-cap: "Hierarchically clustered heatmap of the pairwise Pearson’s correlation coefficients between the time series of allele frequencies in the case study."
#| fig-cap: "Interactive hierarchically clustered heatmap of the pairwise Pearson’s correlation coefficients between the time series of allele frequencies in the case study."
heatmaply_cor(
cor.mat,
Expand All @@ -241,18 +242,17 @@ heatmaply_cor(

### Non-synonymous to synonymous rate ratio over time

To track selection footprints, the substitutions per synonymous site (dS) and
per non-synonymous site (dN) for each sample with respect to the reconstructed
ancestral sequence have been calculated (@fig-evo). Also $\omega$ (dN/dS) is shown in @fig-omega.
To track selection footprints, the substitutions per synonymous site ($dS$) and
per non-synonymous site ($dN$) for each sample with respect to the reconstructed
ancestral sequence have been calculated (@fig-evo), as well as their ratio ($\omega = dN/dS$; @fig-omega).

::: {.panel-tabset}

## dN and dS
![Time series of dN and dS. Each point corresponds to a different sample, sorted in chronological order.](`r params$evo`){#fig-evo}

## $\omega$ (dN /dS)
## $\omega$ ($dN/dS$)

![Time series of $\omega$ (dN/dS). Each point corresponds to a different sample, sorted in chronological order.](`r params$omega_plot`){#fig-omega}
![Time series of $\omega$ ($dN/dS$). Each point corresponds to a different sample, sorted in chronological order.](`r params$omega_plot`){#fig-omega}

:::

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