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Researchers involved
Prof Tim Willson (@tmw20653), University of North Carolina Chapel Hill, READDI-AViDD Co-lead
Prof Ralph Baric at UNC Gillings School of Global Public Health, READDI-AViDD Co-lead
Prof Matthew Todd (@mattodd), University College London, Head of Chemistry Networks at the SGC.
Dr Rebecka Isaksson, University College London (@RebeckaIsaksson). Dr Isaksson manages this repository and is synthetic lead.
The Green site was identified by Dr Konstantin Popov (@kipUNC) and Prof Alex Tropsha at the UNC Eshelman School of Pharmacy.
Dr Popov also lead the virtual screening campaign that generated the initial hit and in addition supports the project with a computationally guided SAR-exploration - the second expansion was proposed from Enamine REAL was proposed by James Wellnitz at the UNC Eshelman School of Pharmacy, and Dr Popov.
Confirming the Green site's conserved status through mutagenic studies was performed by Prof Ralph Baric at UNC Gillings School of Global Public Health, and Dr Vic Tse at St Louise University, School of Medicine.
The picogreen assay and GCI/WaveDelta assay for the intial selection of compounds for this project was done by Dr Tina Leisner in the lab of Dr Ken Pearce at the UNC Eshelman School of Pharmacy.
The picogreen assay was later moved to the labs of SGC in Toronto, where it is run by Dr Sumera Perveen, who also performs biophysical assays (SPR) and aggregation studies.
The antiviral activity studies are performed by Dr Jessica Smith in the lab of Dr Alec Hirsch at the OHSU Vaccine and Gene Therapy Institute. Dr Smith also runs the Huh7-cell line toxicity tests.
Additional test on human cell lines were performed by Heather M Froggatt, Yeepeng Chan, and Audrey K Williams in the lab of Prof Ralph Baric at UNC Gillings School of Global Public Health.
Dr Peter Brown, University North Carolina Chapel Hill, Chemical Probes manager - @toluene44
Dr Rahman Saleem, University College London, UCL site Project manager - @rahmanszsaleem
Dr Anwar Hossain, University North Carolina Chapel Hill, UNC Compound manager - @ahsgc
Dr Ava Vargason, University North Carolina Chapel Hill, Research Program Manager
Taylor Shoun, University North Carolina Chapel Hill, Project Manager