Dependoparvovirus Extension Data
Dependoparvoviruses are a genus within the subfamily Parvovirinae. They possess a remarkably broad host range encompassing all major amniote vertebrate lineages from squamate reptiles to primates.
Most members of this genus cannot replicate autonomously. They require co-infection with a helper virus, such as adenoviruses or herpesviruses, which provide essential replication factors. These helper-dependent adeno-associated viruses (AAVs) do not seem to cause disease under normal circumstances. However, the genus also includes other, autonomously replicating virus species that can cause severe disease (e.g. the autonomous waterfowl viruses).
AAVs are widely used as gene therapy vectors. They are considered non-pathogenic and have a low immunogenic profile, making them attractive candidates for gene therapy. AAV vectors can lead to long-term gene expression in non-dividing cells, making them useful for treating genetic disorders like muscular dystrophy, hemophilia, and retinal diseases.
Tabular data summarising dependoparvovirus species reference sequences can be found here.
Multiple sequence alignments (MSAs) spanning complete dependoparvovirus genomes can be found here.
Parvovirus-GLUE by Robert J Gifford Lab.
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